Therefore, the expression of glycosylated ACE2 in type 2 diabetes mellitus (T2DM) patients is higher than that in non-T2DM patients, and promotes myocardial fibrosis by reducing the expression of Ang 1 to 9, Ang 1 to 7, and MasR, resulting in impaired cardiac function. The gene discussed is ANGPT1; the disease is type 2 diabetes mellitus.