To investigate whether there is a potential causal relationship between clinical risk factors and ACE2 levels, Narula et al[2] showed that genetically higher body mass index and higher risk of type 2 diabetes were associated with elevated plasma ACE2 levels through the Mendelian randomization analysis, However, there was no significant correlation between genetic susceptibility to smoking, elevated low-density lipoprotein and systolic blood pressure with plasma ACE2 levels. The gene discussed is ACE2; the disease is type 2 diabetes mellitus.