Previous studies have shown a significant increase in plasma ACE2 activity after myocardial infarction.[26] However, Ramchand et al[23] showed that plasma ACE2 activity increased even without acute myocardial injury in patients with obstructive coronary disease, which might reflect the potential atherosclerosis of the coronary artery rather than myocardial infarction. The gene discussed is ACE2; the disease is atherosclerosis.