TTN and familial dilated cardiomyopathy: ACM-causing mutations have also been found in nondesmosomal genes such as phospholamban (PLN), filamin-C (FLNC), desmin (DES), titin (TTN), and lamin A/C (LMNA), which are associated with other CMP, such as DCM and neuromuscular CMPs, and may lead to overlapping phenotypes.