PPP6C and cancer: Here, we focus on two regulators of mitotic spindle formation, Aurora A and PPP6C, the catalytic subunit of protein phosphatase 6 (PP6), which are either amplified or undergo loss of function mutations in cancers, respectively (Anand et al., 2003; Bischoff et al., 1998; Hammond et al., 2013; Hodis et al., 2012; Krauthammer et al., 2012; Sen et al., 1997).