The same method is also useful in screening for hotspot mutations in IDH1/2 through the detection of elevations in 2-hydroxyglutarate and especially its D-enantiomer but has less relevance in confirming the pathogenicity of these variants, since they are well described in the literature for many different tumor types and occur somatically (Dang et al. 2016). The gene discussed is IDH1; the disease is neoplasm.