TNF and Tremor: However, after dividing the scores on Part III of the UPDRS into tremor, AR, and PIGD subscores, we noted that baseline plasma EV-derived IL-1β, TNF-α, and IL-6 levels were significantly and positively associated with tremor subscores at follow-up and that baseline plasma EV-derived IL-1β, TNF-α, IL-6, and IL-10 levels were significantly and positively associated with PIGD subscores at follow-up.