MAPT and memory impairment: Intraventricular administration of OA can cause memory impairment in laboratory animals in a water maze [23]; After low dose administration of 100 nM for 2 weeks, tau protein was induced at tau-S396 and tau-t231 sites in brain slices, but only weak phosphorylation occurred at tau-S199 sites, and tau-s396 and tau-t231 sites were induced by 100 nM at hyperphosphorylation [24].