By tiling (Box 1) a 178-kilobase region around IL2RA in Jurkat-dCas9-VP64 cells (Box 1), the screen uncovered six putative enhancers, including an intronic region containing rs61839660 – the SNP associated with Crohn's disease and type 1 diabetes mellitus. Here, IL2RA is linked to type 1 diabetes mellitus.