Co-supplementation was also associated with an improvement in some metabolic profiles including significantly reduced hs-CRP (p < 0.001) and significantly increased total antioxidant capacity (p < 0.001), significantly lower insulin levels (p < 0.001), significantly lower homeostasis model of assessment-insulin resistance (HOMA-IR) (p < 0.001) and increased quantitative insulin sensitivity check index (QUICKI) (p < 0.006); it was associated with significantly decreased serum triglycerides (p = 0.02) and significantly improved (p < 0.05) cholesterol profiles. The gene discussed is INS; the disease is Insulin resistance.