In fact, MTHFR C677T and A1298C gene polymorphisms have been widely studied in various cancers, such as hepatocellular carcinoma [13],colorectal cancer [14], non–Hodgkin’s lymphoma [15], breast cancer [16], etc., while their association with susceptibility to GC has been extensively studied, the findings are still inconclusive [8,9,17–64]. The gene discussed is MTHFR; the disease is gastric cancer.