Importantly, G9a has been shown to be overexpressed and correlated with poorer prognosis and malignancy in several solid tumours including HCC, head and neck squamous cell carcinoma, oesophageal squamous cell carcinoma, Ewing sarcoma, lung, breast, ovarian and colorectal cancers [13, 14, 15, 16, 17, 18, 19, 20]. The gene discussed is EHMT2; the disease is colorectal cancer.