To investigate if epithelial‐mesenchymal transition (EMT) markers were altered upon G9a depletion, we performed a qRT‐PCR of key EMT genes and observed that SNAI1, SNAI2, ZEB1 and TWIST1 were significantly reduced in G9a‐depleted HCC cells (Fig. 4E). Here, EHMT2 is linked to hepatocellular carcinoma.