POLQ was abundant (n = 7), and AXIN2 (n = 2), MSH3 (n = 2), CDH1, LRP6, MLH1, MSH2, MSH6, NTHL1 and LEV3L (n = 1 each) were identified, and the same variant of CDH1, c.2638G>A (p.Glu880Lys), was also identified in one 67-year-old woman (NPaMC) with hepatocellular carcinoma and colon cancer. The gene discussed is MSH2; the disease is malignant colon neoplasm.