IL6 and heart failure: When assessed as a continuous variable and after adjustment, 1 log unit increase in IL-6 was associated with a higher risk of all-cause mortality (HR, 1.46 [1.17–1.81], P=0.001), cardiovascular death (HR, 1.40 [1.10–1.77]; P=0.005), and subsequent heart failure hospitalization (HR, 1.24 [1.01–1.51]; P=0.044; Table 5 and Figure 2).