To investigate the role of macrophage DCLK1 in atherosclerosis, macrophage‐specific DCLK1 knockout mice with an ApoE knockout background (ApoE−/−DCLK1MCKO) and the control DCLK1‐flox mice with an ApoE knockout background (ApoE−/−DCLK1f/f) were generated and used (Appendix Fig S1A and B). Here, APOE is linked to atherosclerosis.