SAMP8 mice were assessed between the 4th and 7th month of age, a timeframe where many of the neuropathological processes have already started (e.g., neuronal loss, microgliosis) or are starting to build up (e.g., Aβ deposition and hyperphosphorylation of tau) (9), and where cognitive impairment is already present (13, 29, 30). This evidence concerns the gene MAPT and Cognitive impairment.