Interestingly, besides risperidone, shown in our study, vafidemstat {a KDM1A and MAOB inhibitor, currently in clinical development for borderline personality disorder and the associated agitation/aggression symptoms [NCT04932291 (32)]}, also attenuated aggressive behaviors in 6 to 7 months old SAMP8 mice (23). The gene discussed is MAOB; the disease is Borderline personality disorder.