Also, it was demonstrated that miR-1 negatively regulates the protein expression of its target gene G6PD, limiting its function of generating ribose-5-phosphate and NADPH, which are promoters of glycolysis and nucleotide biosynthesis in tumor cells; therefore, pituitary tumor tissues under expressing miR-1 showed an augmentation of G6PD (C. He et al., 2018), suggesting miR-1 as a target to diagnose and treat pituitary tumors. Here, G6PD is linked to pituitary tumor.