To determine the impact of DICER1 hotspot mutations on miRNA synthesis, we analyzed the differential miRNA expression in DICER1-mut DTC (six fvPTC and two FTC) vs non-neoplastic/adenomatous thyroids (n=26) using the HTG Edgeseq miRNA whole transcriptome assay which evaluates the expression of 2,083 human mature miRNAs. This evidence concerns the gene DICER1 and thyroid cancer, nonmedullary, 2.