To understand the molecular mechanisms (gene networks and signaling pathways) underlying tumorigenesis of follicular cells harboring DICER1 mutations, we analyzed the mRNA expression profiles of the same pediatric thyroid tumors using the HTG Edgeseq OBP panel, which evaluates the mRNA expression of 2,559 genes related to cancer (Supplemental Table 2). This evidence concerns the gene DICER1 and cancer.