Interestingly, this appears to be exclusive to thyroid cancers as in other tumor types such as endometrial cancers, pleuropulmonary blastomas, sarcomas, Sertoli-Leydig cell tumor, colorectal cancer, and cutaneous melanoma, DICER1 hotspot mutations frequently co-occur with MAPK alterations and/or other driver alterations (10, 46). Here, DICER1 is linked to Sertoli-Leydig cell tumor.