DICER1 and thyroid cancer, nonmedullary, 2: Principal component analysis (PCA) revealed that a classifier with as few as four 3p-miRNA markers (miR-20a-3p, miR-30d-3p, miR-99b-3p, and miR-450a-1-3p) could efficiently distinguish DICER1-mut DTC (regardless of histology: PTC or FTC) from non-neoplastic/benign hyperplastic and DICER1-wt PTCs/FTCs (Figure 2A).