ADIPOR1 and cancer: Figures 5C, D exhibited the DNA methylation levels of ADIPOR1/2 across cancers, respectively. The DNA methylation level of ADIPOR1 was downregulated in BLCA, LIHC, PAAD, and UCEC, but was upregulated in BRCA, HNSC, LUAD, and LUSC. The DNA methylation level of ADIPOR2 was downregulated in BLCA, BRCA, KIRC, LIHC, LUSC, and PAAD, but was upregulated in UCEC. ADIPOR1/2 also exhibited a wide correlation with DNA methyltransferases (Figures 5E, F) and m6A enzymes (Figures 5G, H).