According to the results of univariate cox analysis and Kaplan-Meier plot analysis, ADIPOR1 was identified as a risky factor in ACC and LGG, and its overexpression was associated with their OS and DFS; ADIPOR2 was identified as a favorable factor in KIRC and a risky factor in MESO. The gene discussed is ADIPOR1; the disease is adrenal cortex carcinoma.