In severe COVID-19 patients, it is known that multiple organ failure is observed two to three weeks after the onset, but recent important cohorts of patients with COVID-19 requiring hospitalization have demonstrated that liver injury markers, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), were increased sharply only 1 day after admission (4). This evidence concerns the gene GPT and Multiple Organ Failure.