IDO1 and infection: Indeed, while in WT mice fungal growth was significantly greater at night since early infection times, IDO1 KO mice infected at ZT12 always displayed low CFU count (Fig. 4B) and increased resistance to lung colonization, as shown by the higher PMN recruitment (Fig. 4C), lung inflammatory cells infiltration (Fig. 4D) and cytokines expression (Fig. 4E) observed early 1 day following infection.