LRRK2 and Parkinson disease: Lin et al. (2015) found that in Drosophila melanogaster, loss of function for dLRRK (Drosophila LRRK2) enhances cis-transport of GOPs, while overexpression of dLRRK inhibits cis-transport of Golgi. LRRK2 mutant G2019S promotes retrograde transport and increases the number and size of fixed GOPs located in Golgi vesicle branching sites in dendrites (Horton et al., 2005). This study shows that human LRRK2, similar to dLRRK which is crucial for GOPs regulation and contributes to PD development (Lin et al., 2015).