LRRK2 and Parkinson disease: In vivo, several familial PD mutations enhanced LRRK2 autophosphorylation on Ser1292 including R1441G/C, N1437H, G2019S, and I2020T, which suggest that Ser1292 autophosphorylation may be an indicator of LRRK2 kinase activity (Sheng et al., 2012).