MAPT and Cognitive impairment: Research diagnostic criteria for the clinical syndrome of CTE are known as traumatic encephalopathy syndrome.29–31 Core clinical features of traumatic encephalopathy syndrome include cognitive impairment (i.e. deficits in episodic memory and/or executive functioning) and neurobehavioural dysregulation (e.g. explosiveness, impulsivity and emotional lability).30 The diverse clinical phenotypes reported among individuals exposed to RHI are likely driven by both tau and non-tau aetiologies.31 Exposure to RHI is indeed being increasingly linked with mixed pathologies.32–36