MAPT and Alzheimer disease: Flortaucipir PET in case BI (Fig. 3F–J) also shows widespread neocortical uptake with marked binding in occipital, posterolateral temporal, parietal, posterior cingulate gyri, peri-Rolandic regions and premotor cortex with milder uptake in the remaining frontal lobes, also in keeping with an ‘advanced Alzheimer’s disease tau pattern’.