MAPT and early-onset autosomal dominant Alzheimer disease: The flortaucipir PET study of case BII (Fig. 3K–O) demonstrates neocortical uptake in several regions, particularly in the occipital, posterolateral temporal, parietal lobes and to a lesser degree in the frontal regions involving the peri-Rolandic area and premotor cortex presenting an ‘advanced Alzheimer’s disease tau pattern’.