Flortaucipir PET in case BI (Fig. 3F–J) also shows widespread neocortical uptake with marked binding in occipital, posterolateral temporal, parietal, posterior cingulate gyri, peri-Rolandic regions and premotor cortex with milder uptake in the remaining frontal lobes, also in keeping with an ‘advanced Alzheimer’s disease tau pattern’. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.