Activated FGFR4 interacts with fibroblast growth factor receptor substrate 2 (FRS2), recruits growth factor receptor binding protein (GRB2) and affects downstream proteins mediating osteosarcoma cell proliferation (Vainikka et al., 1994; Ho et al., 2009; Wu et al., 2011). This evidence concerns the gene FGFR4 and osteosarcoma.