Another peculiar mechanism of CV toxicity was observed by Linette et al. (40), that firstly described two cases of fatal myocarditis and cardiogenic shock occurred as a result of cross-reactivity of engineered T cells expressing an affinity-enhanced receptor against MAGE-A3 (melanoma-associated antigen-3), which cross-reacted with titin, a myocardial protein. This evidence concerns the gene MAGEA3 and myocarditis.