EPO and chronic kidney disease: Similarly, a mouse model for advanced chronic kidney disease exhibited decreased hemoglobin, hematocrit and splenic EPOR gene expression as well as increased erythrocyte asymmetric dimethylarginine, suggesting that erythrocyte accumulation of asymmetric dimethylarginine and suppression of EPOR contribute to impaired erythropoietin response (Yokoro et al., 2017).