Since the ratios between M1/M2 macrophages and TH1/TH2 T cells are increased in obese WAT, the induction of an M2-macrophage phenotype in adipose tissue is linked to an improvement of this metabolic disorder by increasing insulin sensitivity (Kang et al., 2008; van den Berg et al., 2017; Brestoff and Artis, 2015). The gene discussed is INS; the disease is metabolic disease.