When stratified by biological factors, the sufficient PA-phosphoprotein expression association was more apparent in women with overweight or normal weight (vs. those with obesity), being menopause (vs. premenopausal), without diabetes (vs. with diabetes), with higher (vs. lower) total energy intake, and having earlier [0/I; vs. more advanced (II–IV)] stage of breast cancer, smaller (vs. larger) tumors in size, ER+ (vs. ER−) tumors, and lymph node-negative (vs. lymph node-positive) disease. Here, ESR1 is linked to obesity due to melanocortin 4 receptor deficiency.