In mammary tumors, levels of p-Akt (Ser473), p-P70S6K (Thr398), and p-4E-BP1 (Thr37/46) detected by Western blotting were downregulated in the PA group as well as in the mildly restricted energy group albeit to a lesser extent, both compared with sedentary controls. Here, EIF4EBP1 is linked to breast cancer.