Many non-invasive or minimally-invasive parameters were associated with inflammatory bowel disease activity or severity in recent years, including clinical features such as stool frequency and hematochezia (3); blood indicators such as C-reactive protein, erythrocyte sedimentation rate, serum amyloid A, ferritin transferrin, haptoglobin, vitamin D (Vit D), albumin (ALB), fibrinogen (Fbg), white blood cell count, platelet count, and cytokines; fecal indicators such as fecal occult blood, fecal immunochemical test, calprotectin, and lactoferrin (4–7). This evidence concerns the gene CRP and inflammatory bowel disease.