Some genetic variations, such as those found in the hemoglobin subunit beta (HBB), ABO blood group (ABO), ATPase plasma membrane Ca2+ transporting 4 (ATP2B4), glucose-6-phosphate dehydrogenase (G6PD) and CD40 ligand (CD40LG) loci, have been associated with attenuation of severe malaria (61). The gene discussed is CD40LG; the disease is malaria.