HLA-A*11:01 is associated with multiple forms of male infertility; HLA-DQB1*03:02 and HLA-A*29:02 are associated with oligozoospermia, and HLA-A*29:02 can also interfere with sperm count with HPV, as well as risk genes associated with oligozoospermia, they are HLA-DQA1*05:01, HLA-C*03:03, and HLA-DQB1*03:01.HLA was associated with male infertility and HPV to further explore the multiple influencing factors of male infertility (121). This evidence concerns the gene HLA-DQB1 and male infertility.