Interestingly, we innovatively found a lower DDR score was positively associated with the activation of most types of immune cells, including macrophages, memory B cells, effector memory CD8+ T cells, central memory CD4+ and CD8+ T cells, natural killer cells, and neutrophils, pointing out that the interaction of a decreased DDR score with the activation of immune responses may be a novel mechanism contributing to the poor prognosis in AD. This evidence concerns the gene CD4 and Alzheimer disease.