RCTs: randomized control trials; CVD: cardiovascular disease; PCSK9: proprotein convertase subtilisin/kexin type 9; MI: myocardial infarction; NR: not reported; ACS: acute coronary syndrome; MACE: major adverse cardiac events; ASCVD: atherosclerotic cardiovascular disease; LDL-C: low-density lipoprotein cholesterol. Here, PCSK9 is linked to cardiovascular disorder.