Pelletier et al. (2015) also found a marked association between high sclerostin levels and aortic calcification in 53 patients with chronic kidney disease. Some studies have analyzed the behavior of sclerostin among patients with alcoholism or liver disease -although with conflicting reported results (González-Reimers et al., 2013; Wakolbinger et al., 2020; Jadzic et al., 2022; Martín González et al., 2022) but the relationship of sclerostin with vascular changes and/or brain alterations among alcoholics has received little attention. Here, SOST is linked to alcohol dependence.