S100A4 and neoplasm: We demonstrated that in protein level S100A4 and SPARC are more abundantly expressed by the cells of stroma compartments compared to tumor nest [17,69 (10,03–28,65) S100A4 stroma vs. 4,18 (1,31-13,93) S100A4 tumor, p<0,0001 and 16,04 (7,29-29,62) stroma SPARC vs. 2,08 (0,78-7,72) tumor SPARC, p<0,0001)] (Figure 4A).