In colon cancer patients, high SPARC mRNA expression was associated with advanced tumor stage (14,62 ± 1,13 vs. 14,24 ± 1,15; p=0,007), positive lymph node metastasis (14,64 ± 1,12 vs. 14,23 ± 1,13; p=0,003) and positive vascular invasion (14,28 ± 1,2 vs 14,51 ± 0,93, p=0,043) (Figure 2D). Here, SPARC is linked to malignant colon neoplasm.