After adjusting for the clinical and pathological parameters such as age, tumor stage, tumor size, lymphovascular invasion, vascular invasion and lymph node metastasis the S100A4 mRNA expression remained an independent prognostic factor for DFS in the CRC group (HR=3,73; 95% CI [1,917-7,274], p<0,0001) and the CC group (HR=10,52; 95% CI [3,655-30,310], p<0,0001) (Tables 1, 2). This evidence concerns the gene S100A4 and metastasis.