Low protein expression of SPP1 was associated with positive vascular invasion in CRC (1,98 (0,60;3,62) vs. 4,14 (1,23;10,80), p=0,0463) and RC (1,01 (0,41;3,43) vs. 3,75 (1,08;12,23), p=0,0341) and with positive lymphovascular invasion in RC patients (2,47 (0,42;3,53) vs. 3,92 (1,08;12,23), p=0,0210) (Figure 5D). Here, SPP1 is linked to colorectal carcinoma.