SPARC and malignant colon neoplasm: In univariate COX analysis SPARC gene expression more than cut-off predicted worse DSS (HR=2,88; 95% CI [1,377-6,006], p=0,004) and worse PFS (HR=2,06; 95% CI [1,308-3,258], p=0,002) in CRC group, as well as worse DSS (HR=2,64; 95% CI [1,141-6,110], p=0,023) and worse PFS (HR=1,98; 95% CI [1,172-3,360], p=0,010) in colon cancer patients (Table 3 and Supplementary Tables S8, S9).