Kaplan−Meier survival curve indicated that CRC patients in S100A4 high-risk group (>cut-off) had shorter overall survival (OS) (p=0,0159), disease-specific survival (DSS) (p<0,0001), disease-free survival (DFS) (p<0,0001), and progression-free survival (PFS) (p<0,0001) than those in low-risk group (<cut-off) (Figure 1A). The gene discussed is S100A4; the disease is colorectal carcinoma.