SPARC and colorectal carcinoma: SPARC expression was lower in patients with positive lymphovascular invasion (8,76 (5,62;39,13) vs. 26,19 (14,74;40,15), p=0,0091) and positive vascular invasion (7,68 (5,62;15,19) vs. 23,26 (12,84;40,15), p=0,0047) in CRC group; similar trend was observed in the same groups of RC patients (8,76 (5,62;47,06) vs. 27,53 (19,84;41,00), p=0,014; 8,04 (5,78;14,22) vs. 25,06 (15,30;41,00), p=0,0072) (Figure 5C).