SPP1 and rectal cancer: After including the clinical and pathological parameters in multivariate Cox analysis, the SPP1 expression more than cut-off remained independent prognostic factor for short PFS in both colon (HR=2,35; 95% CI [1,294-4,283], p=0,005) and rectal cancers (HR=3,32; 95% CI [1,124-9,809], p=0,029) patients (Supplementary Tables S12, S13).