In univariate analysis, high SPP1 gene expression was prognostic for worse OS (HR=2,12; 95% CI [1,092-4,149], p=0,026) and worse PFS (HR=2,08; 95% CI [1,212-3,585], p=0,007) in colon cancer, and for worse DFS (HR=2,81; 95% CI [1,016-7,741], p=0,046) and PFS (HR=2,78; 95% CI [1,089-7,125], p=0,032) in rectal cancer (Supplementary Tables S12, S13). The gene discussed is SPP1; the disease is malignant colon neoplasm.