S100A4 and malignant colon neoplasm: In univariate COX analysis and Kaplan–Meier survival analysis, the protein level of S100A4 in high-risk group (expression more than cut-off meaning) remained prognostic only for OS in both combined CRC group of patients (HR=2,141; 95% CI [1,152-3,978], p=0,016) and patients with colon cancer (HR=2,679; 95% CI [1,136-6,320], p=0,024) (Figures 5A, B).