Multivariate COX analysis also revealed that prognostic model consisting of S100A4 (HR=8,43; 95% CI [5,296-13,426], p<0,0001), SPARC (HR=1,86; 95% CI [1,141-3,041], p=0,012) and SPP1 (HR=1,86; 95% CI [1,124-308], p=0,058) can be established for the PFS in CRC cohort. This evidence concerns the gene S100A4 and colorectal carcinoma.