SPP1 and neoplasm: Statistical data showed that elevated SPP1 mRNA expression correlated with positive vascular invasion (11,08 ± 2,00 vs. 10,23 ± 2,11; p=0,0017), positive lymphatic metastasis (10,82 ± 2,10 vs. 10,31 ± 2,12; p=0,0205) and advanced tumor stage (10,33 ± 2,11 vs. 10,18 ± 2,13; p=0,048) in combined CRC group.