Kaplan–Meier analysis demonstrated that high-risk group based on SPP1 mRNA level more than cut-off had worse OS (p=0,0312), worse DFS (p=0,0308) and worse PFS (p=0,0018) compared to the low-risk group (<cut-off) in the combined CRC group (Figure 3A). This evidence concerns the gene SPP1 and colorectal carcinoma.