High SPARC gene expression indicated advanced tumor stage (14,58 ± 1,06 vs. 14,3 ± 1,10; p=0,014) and positive lymph node metastasis (14,59 ± 1,05 vs. 14,29 ± 1,09; p=0,00073) in CRC (Figure 2D). Here, SPARC is linked to metastasis.