In previous studies, Transcription factor (SOX2) knockdown decreased the levels of miR-181a-5p and miR-30e-5p in breast cancer cells (53), and STAT1 bound to specific elements within the miR-181a promoter region to inhibit miR-181a expression (54); however, a gap has been existed in the research of the correlation BAP31 and transcription factors. The gene discussed is SOX2; the disease is breast cancer.