The most frequent AE in patients treated with anti-EGFR was folliculitis (any grade 49%, grade 3/4 13%), while the most frequent AEs in patients treated with R/T were hand-foot syndrome (any grade 35%, grade 3/4 6%), hypertension (any grade 24%, grade 3/4 6%), neutropenia (any grade 21%, grade 3/4 15%) and anemia (any grade 12%, grade 3/4 6%]. This evidence concerns the gene EGFR and Decreased total neutrophil count.