SOSTDC1, a BMP4/7 antagonist also regulates hepcidin synthesis, providing a new path for cellular iron deficiency in the thyroid gland through the E4BP4/G9a/SOSTDC1/hepcidin pathway, which can be reduced hepcidin secretion and thyroid cancer cell proliferation (57). This evidence concerns the gene SOSTDC1 and thyroid gland carcinoma.