Low expression of E-cadherin is closely associated with poor prognosis and biological behavior such as advanced clinical stage and lymph node metastasis, while high expression of paired related homeobox 1 (PRRX1) and low zinc expression of finger E-box binding homeobox 1 (ZEB1) are related to high E-cadherin expression and low level of epithelial-mesenchymal transition and tumor angiogenesis in NSCLC patients. The gene discussed is PRRX1; the disease is metastatic malignant neoplasm in the lymph nodes.