Interestingly, a report on CMMR-D patients carrying a biallelic NM_000535.5:c.2002A>G (p.Ile668Val) variant described an attenuated phenotype where the age at first cancer was strikingly different, namely 22 years for carriers of this variant versus 8 years for truncating PMS2 variants (38). The gene discussed is PMS2; the disease is cancer.