MAPT and Cognitive impairment: Drugs targeting the core pathologies of AD (anti-amyloid, anti-tau, and secretase inhibitors) and non-conventional interventions (e.g. probiotics and microbiome-based drugs, metabolism and bioenergetics, photo-oxygenation, SV2A modulators, active on mitochondrial stress, transfusion with young blood, among others)60,61 will need to show efficacy at reducing the risk for cognitive impairment and dementia.