The mutant genes include Cu2+/Zn2+ superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TARDBP), fused in sarcoma/translocated in liposarcoma (FUS/TLS), hexanucleotide expansion repeat in chromosome 9 open reading frame 73 (C9orf72), Optineurin (OPTN), TANK-binding kinase 1(TBK1) and Matrin 3 (MATR3) (Brenner and Weishaupt, 2019). The gene discussed is OPTN; the disease is liposarcoma.