Effector CD8+ T cell lymphocytes migrate to the inflamed lung and clear virus infected airways (1) by killing infected epithelial cells (26) and by producing proinflammatory cytokines (e.g., IFN-γ, TNF-α, IL-17 and CCR5 chemokines) that contribute to the recruitment and in situ activation of additional inflammatory DCs and pDCs at sites of viral infection (55). This evidence concerns the gene IFNG and viral infectious disease.