In light of the enhanced differentiation of CD4+ T cells into Tfh cells taking place in PR8 infected ICAM-1/2-/- MedLNs (Figure 5B), we next asked whether virus specific naïve CD8+ T cells also undergo enhanced differentiation into virus specific CD8+ T effectors and TRM CD8+ cells following infection with PR8-SIINFEKL (OVA257–264 peptide). The gene discussed is CD4; the disease is infection.