ICAM1 and influenza: Nevertheless, the numbers of Vβ8.3+/CD8+ effectors recovered in total lung suspensions of I.T. infected lungs, subjected to a secondary I.T. homosubtypic PR8 influenza challenge, were higher than in the primary I.N. infection and similar for both WT and ICAM-1/2-/- mice (Figure 7H).