In addition, both virus specific memory CD4+ T cells and memory B cells, likely persisted in ICAM-1/2-/- deficient MedLNs, since ICAM-1/2-/- mice were fully protected from secondary infections with lethal doses of homosubtypic influenza and generated similar levels of virus specific IgGs during these recall responses. The gene discussed is ICAM1; the disease is infection.