Following this study, intraperitoneal injection of AAV9 encoding sgRNA against three genes critical for the heart, Myh6, Sav1, and Tbx20, in postnatal cardiomyocyte-Cas9 transgenic mice caused a similar degree of DNA disruption and subsequent mRNA downregulation, but only Myh6 disruption induced HCM and heart failure, suggesting that the effect of postnatal cardiac genome editing is target-dependent [147]. The gene discussed is MYH6; the disease is heart failure.