In the same direction, using transgenic mice that express the chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe) and mutant human presenilin 1 (PS1-dE9) together with the sterol regulatory element-binding transcription factor 2 (SREBF2), we have shown that brain cholesterol enrichment accelerates and worsens AD pathology including neuroinflammation, by enhancing the mitochondrial oxidative stress elicited by Aβ [21]. Here, PSEN1 is linked to Alzheimer disease.