PLAGL1 and central nervous system neoplasm: One of the CNS-PNET tumours, from a long-term survivor, was by methylation classified as a CNS embryonal tumour with PLAG-family amplification, a proposed novel rare paediatric CNS tumour type characterized by amplification of one of the PLAG family genes (PLAGL1 or PLAGL2) and a specific methylation profile [27].