One tumour had the histopathological diagnosis of a sarcoma NOS but was classified by methylation profiling as a supratentorial ependymoma, ZFTA fusion-positive, subclass E. The tumour displayed histopathological features of a sarcomatous tumour and showed no nuclear accumulations of p65 (RELA) and might represent an ependymoma with an alternative fusion partner other than RELA, as previously described [23]. Here, RELA is linked to ependymoma.