FOXR2 and embryonal neoplasm: In a study by Sturm et al., DNA methylation profiles from 323 CNS-PNETs were analysed [12] and four other embryonal tumour types were then defined including CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2) and CNS high-grade neuroepithelial tumour with BCOR alteration (CNS HGNET-BCOR).