RHOA and breast cancer: Multiple RAP1 signaling pathway factors, such as RAP1A, RAP1B, CDC42, MAPK2K6, RHOA, ITGB1, ITGB2, ACTB, and ACTG1, were inversely correlated with TTC17 in the coexpression assessment using the METABRIC dataset, which underscored the role of this pathway in the TTC17-mediated metastatic capacity of BC (Fig. 4e).