Many of the genes significantly correlated with CPSP in this study are associated with the pathogenesis of arthritis, including BCAP29, IDO2, IGFBP1, TLR10, and TNC. How these genes regulate and affect chronic pain after arthroplasty requires further exploration [8, 17, 25, 38, 54]. The gene discussed is IGFBP1; the disease is Arthritis.