We further calculated the correlation between CRS and 60 ICGs in GSE78220, and obtained five ICGs that were significantly correlated with CRS, namely CD276, IDO2, TNFRSF4, TNFSF14 and TNFSF18, by screening the correlation coefficient with absolute values greater than 0.7 and P values less than 0.05 (Fig. 5E), among which only CD276 gene showed a significant negative association with CRS. The gene discussed is CD276; the disease is congenital rubella syndrome.