Among 7912 samples across 18 cancer types, we interestingly observed that the majority of the clock control gene, such as HLF, KLF10, FBXL3, TEF, RORs (RORA, RORB, RORC), and NR1D2, are down-regulated in a wide range of cancers (Fig. 1A). The gene discussed is CLOCK; the disease is cancer.