We conducted WGCNA analysis to screen the most prognosis-related modules and RBP genes and further proposed an OS prediction model based on 12 RBP genes (TDRD5, SLFN11, ERFE, LAMA2, APOBEC3D, APOBEC3C, CAPN13, GSR, PLIN4, SLC9A7, FKBP10 and GPC1), which was determined and validated as an independent prognostic factor for CRC patients. This evidence concerns the gene ERFE and colorectal carcinoma.