LIN28B and colorectal carcinoma: Secondly, Xuehui F et al. established a 12-gene model (NOP14, MRPS23, MAK16, TDRD6, POP1, TDRD5, TDRD7, PPARGC1A, LIN28B, CELF4, LRRFIP2 and MSI2), which significantly divided CRC patients into high- and low-risk groups in terms of OS (P < 0.001) [16].