Activation of the PI3K/AKT/GSK3β signalling pathway has been shown to play an important role in oncogenesis and progression of osteosarcoma; and its modulatory pathways are closely related to cell proliferation, migration, cell cycle progression, genetic variation, autophagy, multidrug resistance, and apoptosis [36, 37]. The gene discussed is AKT1; the disease is osteosarcoma.